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​Caring for Tomorrow

A recent medical breakthrough for weight loss could help reduce CVD-related mortality in obese individuals. What could this mean for modern medicine and how might this impact the economy going forward?

According to the American Heart Association (AHA), cardiovascular disease (CVD) is now the leading cause of death in the U.S which is closely linked to obesity. Fortunately, new medical innovations could help reduce the risk of CVD-related mortality in adults who suffer from obesity. What could this mean for modern medicine and how might this impact the economy over the long run?

​​​​Chart showing the economic cost of cardiovascular disease in the U.S. (in billions)​​​​​​​​​​​​​​​​​​
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  • Originally developed in 2005 for the management of type 2 diabetes, GLP-1 (Glucagon-like peptide-1) receptor agonists are a new class of medications that have gained significant attention after receiving approval from the U.S. Food and Drug Administration for weight loss. GLP-1s regulate insulin, slow digestion, and make you feel full more quickly.
  • Obesity prevalence in the U.S. has gone from 30.5% in 1999, to 41.9% in 2020, according to the Centers for Disease Control and Prevention. The AHA estimates that the total economic cost of CVD could reach close to $1.4 trillion by 2035 in the U.S. alone, as seen in the chart above. However, GLP-1s have the potential to help millions of individuals suffering from obesity by lowering the likelihood of CVD and CVD-related deaths.1 Further, we believe GLP-1s could improve the quality of life for millions of Americans by reducing the indirect costs associated with CVD, with the potential to increase overall worker productivity.
  • While the U.S. leads the world in health care costs relative to GDP2​, we believe GLP-1s could reduce costs on CVD-related surgeries over the long-term. Moreover, GLP-1s have the potential to impact other areas of the economy, such as packaged food companies given the reduction in caloric consumption, in our view. Accordingly, we believe that companies who are involved in the production of GLP-1s could potentially have a large opportunity for growth over the long-term.

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1On August 8th, 2023, Novo Nordisk, a Danish pharmaceutical company, published data from their SELECT study on adults who were 45 years or older that were overweight with a diagnosis of CVD, and found that participants who received the GLP-1 medication Wegovy (semaglutide), significantly reduced the risk of CVD related death by 22%. The SELECT study (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity) is a large, randomized, placebo-controlled trial that investigated the effects of semaglutide on the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity and established cardiovascular disease (CVD).
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2Among OECD member countries, the United States had the highest percentage of gross domestic product spent on health care in 2022. The U.S. spent nearly 16 percent of its GDP on health care services. OECD stands for Organization for Economic Co-operation and Development. It is an economic organization consisting of 38 member countries. ​

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​The views expressed are the views of Fred Alger Management, LLC (“FAM”) and its affiliates as of October 2023. These views are subject to change at any time and may not represent the views of all portfolio management teams. These views should not be interpreted as a guarantee of the future performance of the markets, any security or any funds managed by FAM. These views are not meant to provide investment advice and should not be considered a recommendation to purchase or sell securities.

Risk Disclosures: Investing in the stock market involves risks, including the potential loss of principal. Growth stocks may be more volatile than other stocks as their prices tend to be higher in relation to their companies’ earnings and may be more sensitive to market, political, and economic developments. Local, regional or global events such as environmental or natural disasters, war, terrorism, pandemics, outbreaks of infectious diseases and similar public health threats, recessions, or other events could have a significant impact on investments. Foreign securities involve special risks including currency fluctuations, inefficient trading, political and economic instability, and increased volatility. Past performance is not indicative of future performance. Investors whose reference currency differs from that in which the underlying assets are invested may be subject to exchange rate movements that alter the value of their investments. Investing in innovation is not without risk and there is no guarantee that investments in research and development will result in a company gaining market share or achieving enhanced revenue. Companies exploring new technologies may face regulatory, political or legal challenges that may adversely impact their competitive positioning and financial prospects. Also, developing technologies to displace older technologies or create new markets may not in fact do so, and there may be sector-specific risks as well. As is the case with any industry, there will be winners and losers that emerge and investors therefore need to conduct a significant amount of due diligence on individual companies to assess these risks and opportunities.
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Important Information for US Investors: This material must be accompanied by the most recent fund fact sheet(s) if used in connection with the sale of mutual fund and ETF shares. Fred Alger & Company, LLC serves as distributor of the Alger mutual funds.

Important Information for UK and EU Investors: This material is directed at investment professionals and qualified investors (as defined by MiFID/FCA regulations). It is for information purposes only and has been prepared and is made available for the benefit investors. This material does not constitute an offer or solicitation to any person in any jurisdiction in which it is not authorized or permitted, or to anyone who would be an unlawful recipient, and is only intended for use by original recipients and addressees. The original recipient is solely responsible for any actions in further distributing this material and should be satisfied in doing so that there is no breach of local legislation or regulation.

Certain products may be subject to restrictions with regard to certain persons or in certain countries under national regulations applicable to such persons or countries.

Alger Management, Ltd. (85 ​Gresham Street, Suite 308, London EC2V 7NQ, UK) is authorized and regulated by the Financial Conduct Authority, for the distribution of regulated financial products and services. FAM and/or Weatherbie Capital, LLC, U.S. registered investment advisors, serve as sub-portfolio manager to financial products distributed by Alger Management, Ltd.
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Alger Group Holdings, LLC (parent company of FAM and Alger Management, Ltd.), FAM, and Fred Alger & Company, LLC are not authorized persons for the purposes of the Financial Services and Markets Act 2000 of the United Kingdom (“FSMA”) and this material has not been approved by an authorized person for the purposes of Section 21(2)(b) of the FSMA.
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Important information for Investors in Israel: This material is provided in Israel only to investors of the type listed in the first schedule of the Securities Law, 1968 (the “Securities Law”) and the Regulation of Investment Advice, Investment Marketing and Investment Portfolio Management Law, 1995. The Fund units will not be sold to investors who are not of the type listed in the first schedule of the Securities Law. ​

​The American Heart Association (AHA) is a nonprofit organization in the United States that focuses on cardiovascular health through public education, research funding, and advocacy efforts.

The Centers for Disease Control and Prevention (CDC) is a U.S. federal agency that conducts research and provides information to protect public health and safety through the control and prevention of diseases, injuries, and other health hazards.

The Food and Drug Administration (FDA) is responsible for protecting the public health by assuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Statista is a German company specializing in market and consumer data. According to the company, its platform contains more than 1,000,000 statistics on more than 80,000 topics from more than 22,500 sources and 170 different industries.

Alger pays compensation to third party marketers to sell various strategies to prospective investors.

The following positions represent firm wide assets under management as of August 31, 2023: Novo Nordisk A/S 0.04%
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Fre​d Alger & Company, LLC 100 Pearl Street, New York, NY 10004 / www.alger.com​​ ​/ 212.806.8800


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This ETF is different from traditional ETFs.

Traditional ETFs tell the public what assets they hold each day. This ETF will not. This may create additional risks for your investment. Specifically:

You may have to pay more money to trade the ETF’s shares. This ETF will provide less information to traders, who tend to charge more for trades when they have less information.

The price you pay to buy ETF shares on an exchange may not match the value of the ETF’s portfolio. The same is true when you sell shares. These price differences may be greater for this ETF compared to other ETFs because it provides less information to traders.

These additional risks may be even greater in bad or uncertain market conditions.

The differences between this ETF and other ETFs may also have advantages. By keeping certain information about the ETF confidential, this ETF may face less risk that other traders can predict or copy its investment strategy. This may improve the ETF’s performance. If other traders are able to copy or predict the ETF’s investment strategy, however, this may hurt the ETF’s performance. For additional information regarding the unique attributes and risks of this ETF, please refer to the prospectus.

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